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Myc interactors

Web13 feb. 2016 · Abstract. N-myc & STAT Interactor, NMI, is a protein that has mostly been studied for its physical interactions with transcription factors that play critical roles in … Web6 apr. 2015 · The high-confidence MYC interactors identified by BioID are also much more enriched in chromatin-associated proteins (as annotated in the GO database), as compared to the two MYC AP-MS studies; > 50% of the high-confidence BioID dataset is annotated as nuclear, while the Agarwal and Koch datasets contain 17% and 30% nuclear proteins, …

AKT1, LKB1, and YAP1 Revealed as MYC Interactors with NanoLuc …

Web11 jul. 2024 · Using HyPR-MS, 229 c-Myc mRNA-binding proteins were identified, confirming previously proposed interactors, suggesting new interactors, and providing … WebThese include promoter binding, epigenetic modifications, initiation, elongation and post-transcriptional processes. Evidence shows that a combination of multiple protein … rayford crenshaw https://mmservices-consulting.com

Myc and its interactors take shape. - Abstract - Europe PMC

Web1 mei 2015 · Incorporating this global approach to known and novel interactors is a key area for investigation that promises to unveil the relationship of Myc-interacting proteins … Web6 dec. 2024 · MYC Protein Interactome Profiling Reveals Functionally Distinct Regions that Cooperate to Drive Tumorigenesis. Transforming members of the MYC family (MYC, … Web22 mei 2024 · By identifying MYC protein-protein interactors, we aim to gain a deeper mechanistic understanding of MYC as a regulator of gene transcription and potent … rayford caravan park stratford on avon

N-Myc and STAT Interactor (NMI) SpringerLink

Category:N-myc-interactor - Wikipedia

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Myc interactors

MYC regulates ribosome biogenesis and mitochondrial gene …

Web13 jan. 2024 · Our new MYC PPI data confirmed known MYC-interacting proteins, such as MAX, GSK3A, and SMARCA4, and revealed a panel of novel MYC interaction partners, such as RAC-α serine/threonine-protein kinase (AKT)1, liver kinase B (LKB)1, and Yes-associated protein (YAP)1. Web13 okt. 2024 · Focusing on interactors in cis, which dominates the MYC chromatin network (7, 8), we observed that the overlap in interactors present in three different technical …

Myc interactors

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Web27 apr. 2024 · MYC functions as a transcription factor that regulates a diverse set of gene networks including ribosome biogenesis, mRNA translation, microRNA regulation, cell … Web14 mrt. 2024 · Her lab is also pursuing other ways to target Myc, such as finding ways to stabilize a homodimer of two Myc molecules, which would likely end up being degraded …

WebIn brief, it is possible to conceptualize that each MYC molecule in a cell can interact with a specific protein complex at a given time. These complexes can be distinct, and it is the … WebStaff were in constant communication and consultation with us the entire way, and ultimately provided a set of novel high-confidence MYC interactors that we still work on to this …

Web1 apr. 2024 · Comparison between MYC and MYCN-binding proteins has revealed large numbers of common interactors, but also many MYCN-unique interactors. Before … WebNMYC interactor (NMI) interacts with NMYC and CMYC (two members of the oncogene Myc family), and other transcription factors containing a Zip, HLH, or HLH-Zip motif. The NMI …

Web12 mei 2024 · Later, the same group identified protein phosphatase 1 (PP1) and its regulatory subunit protein phosphatase-1 nuclear-targeting subunit (PNUTS) as MYC …

rayford cooksWeb1 jan. 2013 · Identifying Myc interactors. Conducting a protein–protein interactor screen can identify known and novel Myc-binding proteins ( white circle ). Screening … simpletexting import contactsWebThe c-Myc (MYC) transcription factor is a major cancer driver and a well-validated therapeutic target. However, directly targeting MYC has been challenging. Thus, … rayford coatesWeb1 jul. 2005 · The c-Myc NH 2 -terminal domain (MycNTD) is essential for cellular transformation, and mediates critical protein interactions that modulate c-Myc oncogenic … rayford craftWeb29 jun. 2024 · Other MYC interactors, such as transformation/transcription domain-associated protein (TRRAP) and TIP60, also contribute in priming the chromatin … simple texting faqWebTo validate the MYC-G9a interaction, we performed proximity ligation assays (PLAs) in MDAMB231 breast cancer cells. We observed significantly higher fluorescence signal in … simple texting chat jobsWeb1 okt. 2024 · Interestingly, although MYC itself was not captured, many H3 interactors in our dataset appeared to be MYC-related. To formally test this, we compared H3 BioID interactors with the MYC interactome , finding a highly significant overlap (p = 10 −134; Fig. 3G). Proteins interacting with both MYC and H3 were more enriched with H3.3 (Fig. 3H). simple text html