WebNov 1, 2024 · DDR1 is upregulated in human pediatric and adult brain tumors [1, 49]. Little is known about how DDR1 functions in brain cancer, but isoform-dependent functions have been described; for instance, DDR1a, but not DDR1b, was found to be involved in cell invasion and adhesion in gliomas and could activate matrix metalloproteinase 2 (MMP-2) … WebMar 17, 2003 · DDR1, discoidin domain receptor 1, belongs to a subfamily of tyrosine kinase receptors with an extracellular domain homologous to Dictyostellium discoideum protein discoidin 1. We showed that DDR1 is a direct p53 transcriptional target, and that DNA damage induced a p53-dependent DDR1 response associated with activation of its …
Full article: Mechanical signaling through the discoidin domain ...
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DDR1 Protein Overview: Sequence, Structure, Function …
WebNov 1, 2024 · Roles of DDR1 in epithelial cell differentiation 2.1. Promotion of cell differentiation via stabilization of E-cadherin-mediated cell-cell contact E-cadherin-mediated cell-cell adhesion is critical for maintaining epithelial cell differentiation. WebApr 1, 2024 · Under physiological conditions, DDR1 is predominantly expressed in epithelial cells and functions to maintain cell differentiation and tissue homeostasis. A switch in expression from DDR1 to DDR2 ... WebMar 17, 2003 · Inhibition of DDR1 function by DN-DDR1 inhibited irradiation-induced MAPK phosphorylation associated with a detectable decrease in DDR1, p53, pSer15-p53, p21 and Mdm2 levels. Taken together, these findings indicate that DDR1 is an upstream regulator of the Ras/Raf/MEK/MAPK cascade as well as of AKT activation, and that DDR1 … haine sport